In addition, N-desmethyl metabolite AUC and Cmax values significantly increased by two hundred% and seventy nine%, respectively in subjects with severe renal impairment in comparison to subjects with usual renal function.VIAGRA incorporates sildenafil, which is the same medicine found in A further drug named REVATIO. REVATIO is used to treat a unco

Sildenafil is excreted as metabolites predominantly while in the feces (about eighty% of administered oral dose) and also to a lesser extent in the urine (around thirteen% in the administered oral dose). If taken using a large-Unwanted fat food, absorption is reduced; time taken to reach the most plasma concentration improves by around a person hou